Melanotan-2 [Peptide]

Description

What is Melanotan-2 Peptide?

The product is only intended for laboratory research use and not for human consumption. 

Available quantities:

• 10 mg

Product Information 

Product Name	Melanotan-2 Peptide
Peptide purity (HPLC)	98-99%
Molecular Formula	C50H69N15O9
Molecular Weight	1024.2 g/mol
Synonyms	MT-II, MT-2
CAS	121062-08-6
IUPAC	(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
Source	Synthetic
Form	Powder
Shelf Life	Up to 2 years in powder form under recommended conditions

Molecular Sequence of Melanotan-2 Peptide

Ac–Nle–c[Asp–His–D-Phe–Arg–Trp–Lys]–NH₂

• Ac = Acetyl group at the N-terminus
• Nle = Norleucine (a methionine analog)
• c[ … ] = The sequence is cyclized between Asp and Lys
• D-Phe = D-Phenylalanine (non-natural isomer)
• NH₂ = Amidation at C-terminus

Handling and Storage of Melanotan-2 Peptide

The peptide compound should be stored in a cool and dry place to maximize its stability. For Melanotan-2 lyophilized peptides, it is recommended to store them in the refrigerator between 2°C and 8°C (36°F–46°F) in an airtight container. 

Lab user exposure: 

• Avoid prolonged or repeated exposure.
• Avoid inhalation.
• Avoid contact with eyes or skin.
• Handle inside standard laboratory containment.
• Use gloves, a lab coat, and protective eyewear.

Redissolving:

• Can be reconstituted in sterile distilled water or suitable buffer solutions.
• A small amount of DMSO or 0.1% TFA may be used—use only one at a time to assess solubility.
• Mix gently, avoid high-temperature heating. 

Choice of container and precautions:

• Low-binding sterile polypropylene to prevent absorption
• Borosilicate glass vials to prevent absorption in the glass walls
• Avoid polystyrene
• Avoid lab plastic containers 

Overview of the Melanotan-2 Peptide

Melanotan-2 (MT-II) is a synthetic cyclic heptapeptide designed as an analog of the naturally occurring peptide α-Melanocyte Stimulating Hormone (α-MSH). In preclinical research, Melanotan-2 is being studied for its potential effects on melanocortin receptor signaling pathways in laboratory models.

Working Mechanism of Melanotan-2 Peptide

Preclinical studies suggest that the compound may help in activating melanocortin receptors:

• MC1R,
• MC3R,
• MC4R,
• MC5R,
• Laboratory studies suggest that (MT-II) may act through the MC1R receptor, which is present on skin melanocytes, to increase intracellular cAMP levels and activate protein kinase A in experimental models.

• According to laboratory experimental studies, Melanotan-2 may enhance the expression of microphthalmia-associated transcription factors. This factor promotes the activities of enzymes such as tyrosinase involved in melanin production in laboratory models.

• Preclinical studies suggest that MT-2, may also augment the synthesis of eumelanin-the dark, protective melanin form-resulting in increased eumelanin production in research models.

TFA Salt Form 

Melanotan-2 is provided in its TFA salt form. Residual trifluoroacetate content is typically up to 10% w/w. It depends on the final formulation and lyophilization conditions. The exact TFA content can be confirmed by batch-specific COA.

Disclaimer

Melanotan-2 peptide is intended exclusively for laboratory research purposes. RCDbio products are not intended to diagnose, treat, cure, or prevent any disease. The Food and Drug Administration has not evaluated the statements on our website. By purchasing, you agree to our Terms and Conditions.