P21 [Peptide]

Description

P21 [Peptide]

The product is intended for laboratory research only, and not for human consumption.

Available quantities:

• 10 mg

Product Information 

Product Name	P21 Peptide
Peptide purity (HPLC)	98-99%
Synonyms	P021
IUPAC	1-[(2-hydroxynaphthalen-1-yl)disulfanyl]naphthalen-2-ol
Source	Synthetic
Form	Powder
Shelf Life	12-14 months under recommended conditions

Molecular Sequence of P21 Peptide 

Tyr–Gly–Arg–Lys–Lys–Arg–Arg–Gln–Arg–Arg–Arg–Gly–Gly–Val–Pro–Arg–Gln

• Sequence: YGRKKRRQRRR–GGVPRQ
• Length: 17 amino acids

Recommended Handling and Storage 

The compound should be stored in a cool and dry place to maximize its stability. For better storage, it is recommended to keep the P21 Lyophilized peptides refrigerated between 2°C and 8°C (36°F–46°F) in an airtight container.

Lab user exposure: 

• Avoid prolonged or repeated exposure.
• Avoid inhalation.
• Avoid contact with eyes, skin, and clothing.
• The product is non-hazard for laboratory-to-laboratory or air transportation.
• Handle inside standard laboratory containment.
• Use gloves, a lab coat, and protective eyewear.

Redissolving:

• Can be reconstituted in sterile distilled water or suitable buffer solutions.
• A small amount of DMSO or 0.1% TFA may be used to test or improve solubility.
• Mix gently, avoid high-temperature heating or vigorous shaking to avoid degradation of the peptide. 

Choice of container and precautions:

• Low-binding sterile polypropylene tubes to prevent adsorption.
• Borosilicate glass vials to prevent adsorption in the glass walls.
• Avoid polystyrene.
• Avoid lab plastic containers.

Overview of P21 Peptide

P21 is a small sequence peptide derived from a functional region of CNTF ciliary neuropathic factors. ®

Additionally, it is being investigated in preclinical research related to neurotrophic pathways. It is the process of generating new neurons in the brain. This peptide has drawn interest for its potential to enhance cognitive function and promote overall brain health in experimental models.

Working Mechanism of P21 Peptide

Research suggests that P21 Peptide may play a role in supporting memory, learning, and neuron regeneration. While its precise mechanisms of action are still being investigated, P21 Peptide holds promise as a tool for exploring neuroplasticity and developing therapies for neurological conditions.

• P21 may play an important role in diverse cellular processes.®  
• As contains a segment of protein kinase C PKC regulatory domain and fused to poly-arginine transport sequence (YGRKKRRQRRR) to ensure intracellular delivery across the plasma and nuclear membrane. 
• At the molecular level, P21 binds the C1 regulatory subunit of PKC isoforms, disrupting diacylglycerol (DAG)-mediated activation and kinase signaling. Modulation of PKC pathways, cytoskeletal remodeling, calcium mobilization, and apoptotic signaling cascades has been observed in cell-based research models.®

With working mechanisms, here are some common side effects of the compound observed in different research models.

• Headache 
• Dizziness
• Cellular stress
• Off-target pathways modulation
• Vomiting

TFA Salt Form 

P21 peptide is provided in its lyophilized TFA salt form. Residual trifluoroacetate content is typically up to 10% w/w. It depends on the final formulation and lyophilization conditions. The exact TFA content can be confirmed by batch-specific COA.

Disclaimer

P21 peptide is intended exclusively for laboratory research purposes. RCDbio products are not intended to diagnose, treat, cure, or prevent any disease. The Food and Drug Administration has not evaluated the statements on our website. By purchasing, you agree to our Terms and Conditions.

For queries, complaints, or support, please contact support@rcdbio.co.