Introduction

In traditional Chinese medicine, Scutellaria radix (SR) has been utilized for a long time to  potentially treat a variety of health issues. Baicalin stands out among the compounds found in Scutellaria radix due to its potential for intriguing pharmacological properties, such as its role in studies examining antitumor, antimicrobial, and antioxidant effects. It is important to note, however, that baicalin is only available for research purposes. [R]

What is Baicalin?

Baicalin is a flavonoid compound found in several plant species, including Scutellaria baicalensis (Chinese skullcap). It is known for its antioxidant and anti-inflammatory properties and has been used in traditional Chinese medicine for its potential health benefits. Baicalin is studied for its role in supporting immune function, reducing oxidative stress, and promoting overall health.

Since 1889, extensive research into the chemical composition of the Scutellaria genus has led to the isolation of over 295 compounds from 35 distinct species. The majority of these compounds consist of phenolic compounds, such as flavonoids and phenylethanoid glycosides, and terpene compounds, such as iridoid glycosides, diterpenes, and triterpenoids. Scutellaria plants also contain alkaloids, phytosterols, polysaccharides, and other substances.In addition to baicalein and baicalin, thirty other flavonoid compound are detected in the roots of Scutellaria baicalensis Georgi.

Baicalin and baicalein have garnered significant attention from pharmaceutical industries due to their remarkable biological properties. These two flavonoids may have distinct effects on mammalian cells despite their structural similarity and ability to be converted into one another during metabolism. Extensive research has revealed that these compounds possess potential antiviral, antioxidative, antitumor, antithrombotic, antiapoptotic, and neuroprotective properties, making them valuable compounds with a variety of potential health benefits. [R]

Key Features of Baicalin

RCD.Bio offers  Baicalin with the following specifications:

• A purity of 98%, verified by third-party laboratory testing.
• Baicalin is Available in capsule form
• CAS Number: 21967-41-9
• Molecular weight: 446.4 g/mol
• Molecular Formula: C21H18O11
• Synonyms: 7-D-glucuronic acid-5,6-dihydroxy-flavone , Baicalein 7-glucuronide
• IUPAC Name: (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid

How Does It Work?

In a number of health conditions, baicalin has shown promising anti-inflammatory effects. Baicalein has shown promise in treating heart diseases, especially myocardial fibrosis, by going after certain mechanisms. Myocardial fibrosis is often caused by long-term high blood pressure. It is characterized by inflammation of the heart and an abnormal buildup of collagen fibers, which causes diastolic dysfunction. Researchers have found that baicalein can reduce these effects by turning down inflammatory markers like 12-lipoxygenase (12-LOX), p-ERK, and MMP-9. It also lowers the amount of a protein called brain natriuretic peptide (BNP), which makes it a possible treatment for cardiac fibrosis.

Further, Baicalein has also demonstrated significant potential in mitigating renal fibrosis, a common outcome of Chronic Kidney Diseases (CKD). In a mouse model of CKD induced by unilateral ureteral obstruction (UUO), baicalein administration reduced the accumulation of fibronectin and collagen. This effect was achieved by suppressing inflammation and inhibiting the epithelial-mesenchymal transition (EMT) process, crucial in the pathogenesis of renal fibrosis. The compound achieves this by inhibiting the activity of NF-κB and MAPK signaling pathways, ultimately reducing fibrogenic cytokines and alleviating inflammation.

These results show that baicalin has many potential anti-inflammatory properties. This makes it a good candidate for treating a wide range of inflammatory and autoimmune diseases, but more research is needed to confirm its clinical effectiveness.

Potential Benefits of Baicalin

Numerous research investigations and trials on animals suggest that Baicalin may have a number of benefits.

 Baicalin and Cardiac Arrest (CA)

Baicalin has also shown promising potential in protecting the heart from damage caused by cardiac arrest (CA). In a study involving rats subjected to CA, baicalin treatment over four weeks significantly improved cardiac function, boosted survival rates from 35% to 75%, and prevented heart tissue necrosis and cell apoptosis.

These findings suggest that baicalin holds promise as a prospective therapy for the treatment of myocardial injury following cardiac arrest, primarily by inhibiting Drp1-mediated mitochondrial fission. This mechanism may help improve cardiac function, enhance survival rates, and prevent further damage to the heart after CA. [R]

 Baicalin and Myocardial Ischemia

Baicalin has demonstrated its potential ability to protect the heart from injury caused by myocardial ischemia and reperfusion (MI/RI). In a study using rat models, baicalin was administered at different doses after inducing MI/RI. The results showed that baicalin significantly improved heart function, reduced cardiac cell death, and restored normal heart tissue structure by limiting inflammation and neutrophil infiltration.

Baicalin’s protective effects were linked to its ability to inhibit the JAK/STAT signaling pathway, specifically phosphorylation of JAK2 and STAT3. This inhibition played a crucial role in reducing inflammation and preventing post-MI/RI myocardial injury.

[R]

Baicalin demonstrates potential in alleviating myocardial injury following ischemia and reperfusion by modulating macrophage behavior and reducing inflammation through the JAK/STAT pathway. However, it’s important to note that this study was conducted in rat models, and further research is required to determine the applicability of potential baicalin treatment for managing complications arising from myocardial ischemia in humans.

 Baicalin and Alzheimer’s disease (AD)

In a study about Alzheimer’s disease (AD), researchers used a rat model of AD in which the buildup of beta-amyloid peptide (Aβ)  is linked to neurodegeneration. The study found that rats that were given Aβ1–42 had trouble learning and remembering, but that these problems were greatly reduced when they were given Baicalin. Baicalin also stopped the damage that Aβ did to the hippocampus. [R]

Baicalin effectively improved Aβ-induced learning and memory deficits, hippocampal injury, and neuronal apoptosis. These findings suggest that baicalin holds potential promise as a preventive intervention for Alzheimer’s disease by mitigating Aβ toxicity through its antioxidant and anti-apoptotic properties. However, further research is needed to determine its potential applicability in human subjects

 Baicalin and Atherosclerosis (AS)

Baicalin has shown significant promise in addressing atherosclerosis (AS), a chronic and progressively inflammatory disease. In a study involving AS mouse models, baicalin treatment administered over a period of 12 weeks led to remarkable improvements. The treated mice exhibited reduced levels of plasma lipids and smaller atherosclerotic plaque areas in the aorta when compared to the AS model group.[R]

Baicalin presents substantial therapeutic potential in addressing atherosclerosis by targeting various facets of the disease, including the accumulation of adipose tissue, oxidative stress, and inflammation. Its ability to modulate pivotal signaling pathways makes it a promising subject for further research, holding the potential to become a valuable treatment option for AS. However, additional studies are needed to validate its efficacy and safety in human subjects.

 Baicalin and Traumatic Brain Injury 

In the context of traumatic brain injury (TBI), Baicalin has shown potential neuroprotective effects. When administered to mice with TBI, Baicalin significantly improved their neurological function, reduced brain swelling, and decreased cell apoptosis in the brain. This protective effect was associated with changes in specific proteins involved in cell survival and apoptosis. [R]

Baicalin appears to offer neuroprotection in TBI by activating a specific cellular pathway (Akt/Nrf2) that helps combat oxidative stress and promotes cell survival. These findings highlight the potential therapeutic value of Baicalin in the context of traumatic brain injury. Nevertheless, further research is necessary to fully understand its clinical applicability and safety in human subjects.

 Baicalin and Anxiety

Baicalein may exhibit anxiolytic-like effects. These effects were observed in a test involving mice subjected to a Vogel conflict paradigm, where both baicalein (at 10 mg/kg, i.p.) and baicalin (at 20 mg/kg, i.p.) increased the acceptance of shocks without altering thirst or shock sensitivity. This anxiolytic-like effect resembled that of known agents targeting 5-HT1A and benzodiazepine site receptors. Importantly, the anxiolytic-like effect of baicalein and baicalin could be reversed by a benzodiazepine receptor antagonist but not a 5-HT1A receptor antagonist. This suggests that baicalein and baicalin may exert their potential anxiolytic effects by interacting with the benzodiazepine binding site of GABAA receptors. [R] Further research is needed to fully understand the mechanisms and potential applications of these compounds for healthcare professional to recommend.

Baicalin and Skin Cells

Research revealed significant anti-inflammatory activity of baicalin-loaded nanovesicles, regardless of the concentration used. These nanovesicles effectively reduced skin damage induced by the application of phorbol ester (TPA), even outperforming dexamethasone, a synthetic drug with anti-inflammatory properties [R] The incorporation of baicalin into ultra deformable vesicles enhances its potential for skin cell health. These nanovesicles offer a promising approach to potentially improve the delivery of baicalin for the treatment of skin inflammation, making it a valuable tool in skincare and dermatological applications.

Precautions to Consider

The information presented here is for educational purposes only and should not be construed as medical advice.  Baicalin  is intended for laboratory research use only and is not intended for human consumption.

Potential Side Effects 

When administered orally, baicalin may potentially lead to side effects such as stomach discomfort, constipation, vomiting, and gastric upset.  [R]

Where Can I Buy  Baicalin Online?

RCD.bio offers  Baicalin for laboratory and research use only. Some companies sell this as a dietary supplement with other ingredients: pullulan polysaccharide ,rice powder, bamboo extract powder, rice extract blend. It is important to note that RCD.bio sells this as research chemical thus the use of it as supplement is not yet established

When buying  Pure  Baicalin, it is important to choose a reputable market seller who provides quality   Baicalin. At RCD.bio, customers can ensure each product is accompanied with a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product. ,

Conclusion

Baicalin, derived from Scutellaria radix (Skullcap), offers a range of potential health benefits, including potential anti-inflammatory properties. Baicalin’s effectiveness has been explored in various health conditions such as heart diseases, autoimmune hepatitis, multiple sclerosis, renal fibrosis, and lung inflammation. Additionally, it exhibits promise in protecting against cardiac arrest and myocardial ischemia. This natural compound’s ability to modulate inflammation and oxidative stress makes it a valuable subject for further research, offering potential therapeutic applications.

Extensive research suggests that baicalin can effectively address various health issues. In lung inflammation caused by exposure to fine particulate matter, baicalin significantly reduces lung injury and improves respiratory function. It also demonstrates potential in treating heart diseases, autoimmune hepatitis, and multiple sclerosis by targeting specific mechanisms. Moreover, in the context of renal fibrosis, baicalin suppresses inflammation and inhibits fibrosis-related processes. These findings highlight the compound’s versatility in combating inflammation and oxidative stress, indicating its potential for a wide range of health benefits. However, further clinical research is needed to confirm its effectiveness in human subjects.

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