Table of Contents
Introduction
Evodiamine group, an extract derived from the Evodiae fructus plant, is a bioactive alkaloid that has been traditionally used in Chinese medicine in weight loss and treat digestive problems.[R] Despite being used for thousands of years, its medical benefits have not been thoroughly studied until recently. The molecular weight of evodiamine is approximately 303.4 g/mol, it is commonly abbreviated as EVO
Studies have shown that evodiamine liquid possesses antioxidant and anti-inflammatory properties, indicating its potential applications in the medical field. Additionally, evodiamine liquid has been found to have thermogenic properties, which raise the body heat and resting core body temperature, leading to its use as a warming agent or “hot herb” in Chinese medicine. [R]
However, it is crucial to note that evodiamine liquid is intended for laboratory research use only and should not be used for human consumption without proper approval and supervision. In this article, we will explore the potential benefits and uses of evodiamine liquid in research and discuss safety considerations and proper usage guidelines for researchers and scientists.
Key Features
RCD.Bio offers Evodiamine with the following specifications:
- A purity of 98%, verified by third-party laboratory testing.
How Does It Work?
Evodiamine is a compound found in the fruit of the Evodia rutaecarpa plant, which has been used in traditional Chinese medicine for centuries. Recent studies have shown possibilities that evodiamine suppresses tumor growth [R]
One of the ways Evodiamine works is by suppressing the proliferation, invasion, and metastasis of cancer cells, which is the spread of cancer cells from the original tumor to other parts of the body. This is due to Evodiamine’s ability in inducing apoptosis, or programmed cell death, which helps to reduce the number of cancer cells in the body.[R]
Another way that Evodiamine works is by impacting metabolism and the release of catecholamines from the adrenal glands. Catecholamines are hormones that prepare the body for physical activity, such as the “fight or flight” response. When taken with certain drugs, Evodiamine can affect the release of these hormones, which can have an impact on the body’s physiological processes.[R]
Interestingly, Evodiamine shares some similarities with capsaicin, a compound found in red peppers. Both compounds can stimulate the body’s receptors, but Evodiamine is less effective than capsaicin, and it takes three times the concentration to produce the same effect. Unlike capsaicin, Evodiamine has no discernible taste or spiciness. [R]
Potential Benefits of Evodiamine
Fat Loss
The results for fat loss are still promising even if evodiamine concentration hasn’t been tested on humans. In a study that was published in 2001, rats given evodiamine demonstrated considerable fat loss when compared to a control group. It was interesting to learn from the study that evodiamine might increase heat production while also causing heat loss. According to this study, eating less prevents weight gain and fat storage. [R]
This prompted the researchers to conclude that evodiamine caused a more efficient use of food energy. The same study suggests that evodiamine may effectively encourage brown adipose tissue thermogenesis or the process of heat production. As a result, the research medicine has a stronger fat-burning impact. [R]
To infer reasonably from the scientific research presented above that evodiamine, like its capsaicin counterpart, has effective metabolism-boosting and fat-loss capabilities without the hot sensation.
Inflammation
Specific research supports the use of evodiamine as a natural pain reliever because it has the capability to prevent the upregulation of COX-2, a pro-inflammatory enzyme. Furthermore, researchers discovered that the potent alkaloid isolated NF-kB, a well-known marker of inflammation. [R]
Inflammation is a natural response of the body to injury or infection, but it can also cause pain, swelling, and discomfort. Many people turn to pain relievers to ease their discomfort, but some of these drugs can have negative side effects. However, recent research has suggested that evodiamine, a compound found in the fruit of the Evodia rutaecarpa plant, may offer a natural alternative for pain relief.
One of the ways that evodiamine works as a natural pain reliever is by preventing the upregulation of COX-2, a pro-inflammatory enzyme. When the body is inflamed, it produces more COX-2, which can lead to pain and discomfort. By blocking the production of COX-2, evodiamine can help to reduce inflammation and relieve pain. In addition to its impact on COX-2, evodiamine inhibits NF-kB, a well-known marker of inflammation. NF-kB plays a key role in regulating the immune system and promoting inflammation. By inhibiting NF-kB, evodiamine can help to reduce inflammation and relieve pain.[R]
It is important to note that while evodiamine has shown promise as a natural pain reliever for inflammation, more research is needed to fully understand its benefits and potential risks.
Inflammations that are caused of plaques in arteries and arthritis have shown effects too which is furthered discussed below.
Atherosclerosis
Atherosclerosis is a chronic inflammatory disease characterized by the buildup of plaque in the arteries. The plaque is made up of fatty substances, cholesterol, cellular waste products, calcium, and fibrin (a clotting material in the blood) that accumulate on the inner lining of the artery walls. Researchers investigated the effect of evodiamine on atherosclerosis in mice significantly reduced atherosclerotic plaque formation and regulated the proliferation, migration, inflammatory response, and oxidative stress in vascular smooth muscle cells by inhibiting the activation of the PI3K/Akt axis. These findings suggest that evodiamine has potential as an anti-atherosclerotic agent. [R]
Osteoarthritis (OA)
The molecular mechanism through which EVO can prevent mouse chondrocytes from degrading and becoming inflamed. Thus, the data of a study suggest that EVO may be a therapeutic choice for the management of OA. [R]
Digestive Issues
The effects of evodiamine on particular digestive problems have been the subject of several investigations utilizing male rats. Evodiamine may reduce stomach emptying and gastrointestinal transit in male rats via a mechanism involving CCK release and CCK1 receptor activation, claim the participating scientists. To establish evodiamine’s ability to treat the reportedly occurring digestive problems, more investigation is necessary. [R]
Cancer
Evodiamine might be a crucial compound in the fight against cancer.
In an investigation, the evodiamine compound suppresses the capacity of colon cancer 26-L5 cells to induce lung metastases in mice by 70%. Evodiamine-treated mice had significantly fewer tumors than the animals in the control group. [R]
Evodiamine does the vegf induced angiogenesis , that may be a promising therapeutic agent for cancer treatment. Its mechanism of action involves the inhibition of VEGF expression, probably through repression of ERK phosphorylation. [R]
Additionally, according to the results of small-scale laboratory investigations, evodiamine shows various molecular mechanism to prevent the growth of human cancer cell lines that are typical of the following types of cancer:
- Acute leukemia [R]
- Malignant melanoma [R]
- Lung cancer [R]
- Prostate cancer [R][R][R]
- Breast cancer [R] and
- Cervical cancer [R]
Alzheimer’s Disease
In a laboratory investigation, the effects of evodiamine on the progression of Alzheimer’s disease (AD) in transgenic mouse models were examined. The findings demonstrated that the study chemical dramatically decreased the neuroinflammation and glial cell activation process in the hippocampus which are common in AD patients. [R]
However, further research is still needed to validate evodiamine’s efficacy in treating AD.
Precautions to Consider
The information presented here is for educational purposes only and should not be construed as medical advice. The Evodiamine is intended for laboratory and research use only and is not intended for human consumption.
The FDA considers evodiamine an experimental drug meaning it should not be taken as a daily supplement. The drug still requires large-scale studies before it can be considered safe for human consumption. The products are only to be used in labs and for study; they are not intended for human consumption.
Potential Side Effects
Substantial cardiotoxicity and hepatotoxicity associated with EVO have been found. [R][R]
Conclusion
Evodiamine is a bioactive alkaloid derived from the plant Evodiae fructus, which has been used in Chinese herbal medicine for diverse biological activities for weight loss and to treat digestive problems. It has thermogenic properties, which make it a warming agent or “hot herb”. Evodiamine’s anti-tumor properties are attributed to its ability to suppress proliferation, invasion, and metastasis, as well as induce cell death or apoptosis. It can also impact metabolism and the release of catecholamines. Evodiamine has been shown to have potential in fat loss, inflammation, atherosclerosis, osteoarthritis, and cognitive disorders such as Alzheimer’s, based on research conducted on animals and in vitro studies. However, more human studies are needed to verify these potential benefits.
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