Introduction

Nooglutyl is a nootropic chemical being studied for its possible cognitive enhancement properties. Nooglutyl, which has been shown to increase memory, learning, and overall cognitive function, is being explored in the context of neuroprotection and mental performance. This introduction discusses Nooglutyl’s role in scientific study, emphasizing on its processes and potential advantages to brain health.

It is important to note that Nooglutyl is only offered for research purpose only, and this article only talks about how it could be used as a research compound.  By this experimental compound recently developed, we hope to find out how it could help us learn more about how the brain works and come up with possible treatments.

What is Nooglutyl?

Nooglutyl belongs to the group of nootropic agent compounds. It is used to improve brain function. Nootropics, which are sometimes called “smart drugs,” are a group of substances that have gotten a lot of buzz because they may improve cognitive processes. Nooglutyl, which is made from L-glutamic and oxynicotinic acids, is an interesting discovery to study in this field.[R]

The Research Institute of Pharmacology at the Russian Academy of Medical Sciences created nooglutyl initially as a potential amnesia treatment. Over time, experts looked into it more, looking for ways it could be used to treat memory and learning problems and to stop ischemic neuronal damage and brain injury.  [R]

Key Features

RCD.Bio offers Nooglutyl powder with the following specifications:

• A purity of 98%, verified by third-party laboratory testing.
• A 1000mg experimental compound in powder form
• CAS Number: 112193-35-8
• Molar Mass: 268.225 g·mol−1
• Chemical Formula: C11H12N2O6
• IUPAC Name: N-[(5-Hydroxy-3-pyridinyl)carbonyl]-L-glutamic acid
• Synonyms: Nooglutil

How Does It Work?

The activation of AMPA receptors occurs through a series of molecular interactions. When glutamate, an excitatory neurotransmitter, is released into the synapse, it stimulates AMPA receptors on the surface of the receiving neuron. Glutamate also interacts with another surface protein called the NMDA receptor. These interactions lead to the production of cyclic AMP (cAMP) and the activation of the CREB protein.

The activation of CREB is essential for memory consolidation as it triggers the activation of genes responsible for synthesizing protein enhancers specific to synapses. Nooglutyl, as an AMPA receptor agonist, aids in memory enhancement by facilitating the depolarization reaction of AMPA receptors to glutamate. Furthermore, it increases the level of active CREB in cells by inhibiting the degradation of cAMP by an enzyme called phosphodiesterase. [R]

Potential Benefits of Nooglutyl

Numerous research investigations and trials on animal models suggest that Nooglutyl may have a number of benefits. 

Stroke Neuroprotection

The potential neuroprotective effects of Nooglutyl have been examined in a study involving rats with induced hemorrhagic strokes. Hemorrhagic strokes occur when there is bleeding in the brain, leading to brain damage. 

The results of the study revealed that the administration of Nooglutyl had a positive impact on reducing brain damage resulting from the induced strokes in rats [R]

While these findings are promising, it is important to note that further research is necessary to fully understand the underlying mechanisms and determine the effectiveness of Nooglutyl as a brain protective function agent in human subjects. 

Chronic Cerebral Ischemia

Nootropics, which are also called “cognitive enhancers,” are being looked at as possible treatments for chronic cerebral ischemia, a condition in which the brain doesn’t get enough blood for a long time. This condition can make you forget things and make you more likely to have a stroke. Some studies have shown that some nootropics, like piracetam, may help people with chronic cerebral ischemia think better.

There are many ways that these drugs may work to help cerebral ischemia. One key benefit is improving blood flow to the brain, ensuring an adequate supply of oxygen and nutrients. Insufficient blood flow can lead to mental issues, which can be alleviated by enhancing blood circulation to the brain.

Neuronal plasticity is the brain’s ability to change and make new connections. It has also been found that nootropics increase this ability. People with chronic cerebral ischemia may be able to recover and keep their cognitive function with the help of this increased plasticity. Nootropics also have antioxidant properties that can reduce oxidative stress in the brain. Oxidative stress is a factor in neurological and psychological disorders or decline, so nootropics’ ability to reduce oxidative stress may be another way they help people.[R]

While the article is mostly about how nootropics work to treat chronic cerebral ischemia, it is important to note that more research is needed to find out the specific effects of Nooglutyl, as well as its possible benefits in this condition.

Brain Injury 

In a study on the effects of two new nootropics, Nooglutyl and GVS-111, the benefits they might have for test subjects with brain injuries were looked at. Nooglutyl is a drug made from L-glutamic and oxynicotinic acids. It is known for its glutamatergic effects and maybe used to treat memory and learning problems and prevent ischemia-related damage to neurons and brain injury. 

The study also looked at GVS-111, which is a “substituted prolyl dipeptide,” and found that it may make the brain work better. It was shown to help test subjects who had trouble learning due to brain damage, scopolamine, shock, or other things. [R]

Another study found that nooglutyl rats may have a protective impact on the brain’s mitochondrial activity following a craniocerebral lesion. The most notable impact of nooglutyl on the effectiveness of mitochondrial oxidative phosphorylation during the posttraumatic period in young rats is when compared to other medications. [R]

The findings demonstrate that Nooglutyl and GVS-111 may be used as interventions for brain injuries. But further study is needed to fully understand how they work and figure out if the effectiveness in human subjects.

Behavior and Memory (Central Nervous System Effects)

Studies on lab animals have shown that nooglutyl may have positive effects on a number of brain functions, especially in the areas of behavior and memory. For example, when given at a dose of 20 mg/kg, Nooglutyl improved the behavior and memory of SAMP10 mice that were 9 months old. These effects included increased locomotor activity in the open field test, reduced anxiety in the raised plus maze test, and improved retrieval of the passive avoidance response. [R]

It is essential to note, however, that while these findings provide insight into the potential cognitive benefits of Nooglutyl, they may not directly apply to humans. To fully comprehend how Nooglutyl influences cognitive function and to determine its efficacy and safety for human use, additional research is required.

Motion/Travel Sickness

Motion sickness, referred to as the “travel sickness,” can happen when you are in a car or on a boat. Symptoms include feeling sick, uncomfortable, and dizzy. Experiments have shown that Nooglutyl, like well-known drugs like scopolamine and diprazine, has strong properties that protect the vestibular system and keep people from getting sick when they move.

Nooglutyl exerts its effects on motion sickness by influencing the spontaneous activity of neurons in specific regions of the cortex, namely somatosensory zone I and area 5 of the parietal association cortex. Approximately 80% of the neurons in these regions show altered activity in response to Nooglutyl. By increasing activity in zone I of the body’s somatosensory cortex and inhibiting neuron responses to somatic stimuli, Nooglutyl significantly reduces the impact of motion sickness.[R]

These findings suggest that Nooglutyl holds promise as a aid for preventing motion sickness. However, further research is needed to fully understand its mechanisms of action and to determine its efficacy for human use in motion sickness situations and how nooglutyl alters spontaneous activity.

Prenatal Exposure to Alcohol

An article talks about a study that uses a chemical called nooglutyl to find out what happens to rats’ central nervous systems when they are exposed to alcohol before birth. Several functional impairments and delays have been linked to alcohol consumption during pregnancy.

According to the study, giving rats the nootropic drug nooglutyl daily from day eight to day twenty of their lives prevented the disruption of higher cognitive functions and brain chemical processes brought on by alcohol exposure. This suggests that nooglutyl may have a protective effect against the negative consequences of prenatal alcohol exposure on cognitive function and brain chemistry in rats. [R]

It is important to note that while this study provides insights into the potential benefits of nooglutyl in mitigating the effects of prenatal alcohol exposure, further research is needed to determine its efficacy and safety in humans and to fully understand its mechanisms of action in this context.

Benzodiazepine Withdrawal

The study looks at how the chemical compound nooglutyl affects the symptoms of benzodiazepine withdrawal and how it affects the way 3H-spiperone binds to D2 receptors in the rat striatum. The results of this trial aim to provide further insights into the effects of nooglutyl on brain dopamine signaling and its potential use in treating benzodiazepine withdrawal.

In the study, rats were administered nooglutyl intraperitoneally at a dose of 70 mg/kg. After 24 hours of not consuming diazepam, the rats exhibited reduced anxiety in the Vogel conflict test. This suggests that nooglutyl may have anxiolytic properties and could potentially alleviate anxiety-related symptoms associated with benzodiazepine withdrawal. [R]

While these findings are promising, it is important to note that further research is necessary to fully understand the effects of nooglutyl on benzodiazepine withdrawal and its potential as a treatment option. Additional studies are needed to investigate its mechanisms of action and to determine its safety and efficacy in human subjects.

Precautions to Consider

When researching Nooglutyl, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals

Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow the recommended dosage in the warning section

Adhere to the recommended dosage instructions outlined on the product label. Avoid a significant increase of the suggested dose to minimize the risk of potential adverse effects among test subjects.

Potential Side Effects [R]

Some common side effects of nootropics may include insomnia, blurry vision, high blood pressure, a fast heart rate, circulation problems, and addiction.

Conclusion

The Institute of Pharmacology Russian has conducted extensive research on Nooglutyl and its outstanding memory retention and recall benefits. Nooglutyl is a derivative of L-glutamic and oxynicotinic acids and is classified as a nootropic chemical drug. It has been developed and researched for its potential applications in treating amnesia, memory and learning disorders, preventing ischemic neuronal damage, and brain injury. Nooglutyl acts as an AMPA receptor agonist, activating glutamine AMPA receptors in neurons. It influences memory creation through membrane depolarization and CREB protein activation.

Studies have shown various potential benefits of Nooglutyl, including neuroprotection in stroke, potential treatment for chronic cerebral ischemia, improvement in cognitive function, protection against brain injury, prevention of motion sickness, mitigation of functional abnormalities caused by prenatal alcohol exposure, and potential utility in benzodiazepine withdrawal. 

However, it is important to note that further research is needed to fully understand the specific effects and safety profile of Nooglutyl benefits memory.

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