Copper Peptide GHK-Cu 2:1 [Peptide]

Description

Copper Peptide GHK-Cu 2:1 

The product is only intended for laboratory research use and not for human consumption. 

Available quantities:

• 5 mg
• 10 mg
• 50 mg
• 100 mg
• 500 mg
• 1000 mg
• 2000 mg

Product Information 

Product Name	Copper Peptide GHK-Cu 2:1
Peptide purity (HPLC)	98-99%
Molecular Formula	C14H22CuN6O4
Molecular Weight	401.9 g/mol
CAS	49557-75-7
IUPAC	6-Amino-2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid
Synonyms	Glycyl-L-Histidyl-L-Lysine; Growth-modulating peptide; Kollaren; Liver cell growth factor; Liver growth factor Cu-GHK; Glycyl-histidyl-lysine, monocopper salt
Source	Synthetic
Form	Powder
Shelf Life	Up to 2 years in powder form under recommended conditions

Molecular Sequence of Copper Peptide GHK-Cu 2:1

Glycine – Histidine – Lysine

Gly–His–Lys
(Sequence: G-H-K)

When bound with copper, the histidine residue binds Cu²⁺ to form the complex:

GHK-Cu (Copper Tripeptide-1)

Chemical structure:
Gly-His-Lys : Cu²⁺

Handling and Storage of Copper Peptide GHK-Cu 2:1

The peptide compound should be stored in a cool and dry place to maximize its stability. For Copper GHK-Cu 2:1 lyophilized peptides, it is recommended to store them in the refrigerator between 2°C and 8°C (36°F–46°F) in an airtight container. 

Lab user exposure: 

• Avoid prolonged or repeated exposure.
• Avoid inhalation.
• Avoid contact with eyes or skin.
• Handle inside standard laboratory containment.
• Use gloves, a lab coat, and protective eyewear.

Redissolving:

• Can be reconstituted in sterile distilled water or suitable buffer solutions.
• A small amount of DMSO or 0.1% TFA may be used to test or improve solubility.
• Mix gently, avoid high-temperature heating. 

Choice of container and precautions:

• Low-binding sterile polypropylene to prevent adsorption
• Borosilicate glass vials to prevent adsorption in the glass walls
• Avoid polystyrene
• Avoid lab plastic containers 

Overview of the Copper Peptide GHK-Cu 2:1

Preclinical studies have indicated that Copper Peptide GHK-Cu 2:1 is a combination of naturally occurring peptides Glycyl-L-Histidyl-L-Lysine (GHK) and copper ions.

In laboratory peptide research, the term 2:1 refers to the molar ratio that includes two molecules of GHK that bind to one copper ion, forming a stable peptide-copper complex. In preclinical studies, it has been detected in plasma, saliva, and urine of research models. 

Working Mechanism of Copper Peptide GHK-Cu 2:1

• In cell culture studies, GHK-Cu 2:1 has been shown to increase the activity of copper-dependent enzymes in experimental models. In addition, GHK-Cu 2:1 was found to act as a copper ion carrier in laboratory models. 
• Lab evidence revealed that GHK-Cu 2:1 caused an increase in extracellular matrix (ECM) protein expression and reduced pro-inflammatory cytokine expression.
• In a few experimental models, GHK-Cu 2:1 was found to influence the expression of various genes involved in inflammation, extracellular matrix production, and oxidative stress response. 

• In experimental peptide research, GHK-Cu 2:1 has been observed to stimulate vascular endothelial growth factor (VEGF) expression, promoting angiogenesis in tissue-engineered constructs.

Along with potential mechanisms the compound also has some laboratory observations in preclinical settings:

• Cell stress
• Gene changes
• Slow growth
• Protein imbalance
• Cell shrinkage
• Variability observed in laboratory experiments

TFA Salt Form 

 GHK-Cu 2:1 is provided in its TFA salt form. Residual trifluoroacetate content is typically up to 10% w/w. It depends on the final formulation and lyophilization conditions. The exact TFA content can be confirmed by batch-specific COA. (R)

Disclaimer

 GHK-Cu 2:1 peptide is intended exclusively for laboratory research purposes. RCDbio products are not intended to diagnose, treat, cure, or prevent any disease. The Food and Drug Administration has not evaluated the statements on our website. By purchasing, you agree to our Terms and Conditions.