PNC-27 Peptide

Product Name: PNC-27
Product Form: 5 mg Lyophilized Powder
CAS Number: 1159861-00-3
Chemical Formula: C₁₈₈H₂₉₃N₅₃O₄₄S
Molecular Mass: 4031.79 g/mol

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What is PNC-27?

PNC-27 is a synthetic peptide recognized for its potential anti-cancer properties. Its sequence incorporates amino acid residues 12–26 from the human p53 protein, a region crucial for binding to the human double minute 2 (HDM-2) protein. RCDbio offers PNC-27 for research purposes, particularly to investigate cellular membrane dynamics and related biochemical processes in oncology.

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How Does PNC-27 Work?

Preliminary studies suggest that PNC-27 binds to HDM-2 proteins overexpressed on the membranes of cancer cells, leading to mechanisms such as:

• Inducing Membrane Pore Formation: The interaction between PNC-27 and membrane-bound HDM-2 results in the formation of transmembrane pores, causing cell lysis and necrosis in cancer cells.

• Disrupting Mitochondrial Function: PNC-27 has been observed to associate with mitochondrial membranes, leading to mitochondrial disruption and contributing to cancer cell death.

Importantly, these effects are selective to cancer cells due to the presence of HDM-2 on their membranes, sparing normal cells that lack membrane-bound HDM-2.

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Applications of PNC-27 in Anti-Cancer Research

Researchers are exploring PNC-27 in areas such as:

• Necrosis Pathways: Studying the induction of necrosis in cancer cells through membrane pore formation.

• Oncogenic Signaling: Investigating interactions with HDM-2 and their impact on tumorigenic pathways.

• Cellular Membrane Structures: Examining the role of membrane-bound HDM-2 in cancer cell susceptibility to PNC-27.

• Peptide-Membrane Interactions: Understanding how PNC-27 binds to HDM-2 and induces pore formation.

• Combination Therapies: Assessing the potential of PNC-27 in conjunction with other anti-cancer agents.

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Potential Research Benefits of PNC-27

Ongoing studies aim to elucidate PNC-27’s involvement in:

• Selective Cytotoxicity: Targeting cancer cells while sparing normal cells due to selective binding to membrane-bound HDM-2.

• Tumor Suppression: Reducing tumor growth in preclinical models through induction of cancer cell necrosis.

Note: The potential benefits and research applications mentioned require further scientific validation regarding the safety and efficacy of PNC-27.

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Why Choose RCDbio for PNC-27?

RCDbio is a leading online retailer of research-grade peptides and compounds, offering PNC-27 with:

• Standard Laboratory Manufacturing: Produced under stringent laboratory conditions.

• High Purity and Stability: Ensured through rigorous quality control measures.

• Third-Party Testing: Verified for quality and consistency by independent laboratories.

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Frequently Asked Questions

Is PNC-27 safe?

PNC-27 is intended solely for controlled research experiments. Researchers should adhere to standard laboratory handling and safety protocols.

Is PNC-27 legally available for research?

PNC-27 is legally available for investigational purposes. However, legality may vary based on local regulations. Researchers are responsible for ensuring compliance with applicable laws.

How to order PNC-27 from RCDbio?

Select the desired quantity and strength (5 mg) and add to the cart. Enter billing details to complete the order securely. For bulk purchases or special pricing, contact our customer support team at support@rcdbio.co.

How to store PNC-27?

Store PNC-27 at 2–8°C in a dark, dry place, away from direct heat and sunlight. Follow standard laboratory protocols for peptide reconstitution.

What is the half-life of PNC-27?

Studies suggest that the half-life of PNC-27 is approximately 30 minutes, depending on its interaction with HDM-2.

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Disclaimer

PNC-27 is intended exclusively for laboratory research purposes. RCDbio products are not designed to diagnose, prevent, or cure any disease. The Food and Drug Administration has not evaluated statements regarding research products on our website. Researchers must ensure compliance with all applicable local laws and regulations. By purchasing, you agree to our Terms and Conditions. RCDbio reserves the right to refuse sales to unauthorized individuals. For queries or support, contact support@rcdbio.co.