L-Tetrahydropalmatine (L-THP) [Powder]

Description

L-Tetrahydropalmatine (L-THP) [Powder]

Preclinical studies have indicated that L-Tetrahydropalmatine (L-THP), also known as (–)-Tetrahydropalmatine. It is a naturally occurring plant-derived alkaloid with the molecular formula C₂₁H₂₅NO₄ and a molecular weight of 355.43 g/mol.

According to experimental studies, it is the levorotatory enantiomer of tetrahydropalmatine, a tetrahydro derivative of palmatine with four additional hydrogens, and represents the active form. L-THP is found primarily in plants of the Corydalis genus (notably Corydalis yanhusuo). L-Tetrahydropalmatine is also found in other species such as Stephania rotunda.

Chemical Properties

PRODUCT TYPE	POWDER
Product Name	L-Tetrahydropalmatine (L-THP)
CAS	483-14-7
IUPAC Name	(13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
Synonyms	Tetrahydropalmatine, Rotundine, L-Tetrahydropalmatine, (-)-Tetrahydropalmatine
Storage	Minimize open-air exposure and store in a cool, dry place
PubChem CID	72301

What is the Working Mechanism of L-Tetrahydropalmatine (L-THP)?

In laboratory experiments, L-THP has been shown to interact with multiple neurotransmitter systems. Here is a breakdown of its working mechanism:

• Dopamine Receptor Modulation

Preclinical and experimental research findings indicate that L-Tetrahydropalmatine (L-THP) acts as a dopamine receptor antagonist at D1 and D2 receptors. L-THP demonstrates activity at dopamine D3, and also interacts with alpha-adrenergic and serotonin receptors.

This modulation helps regulate dopaminergic pathways, which in experimental models have been linked to addiction, stress, and reward-seeking behavior.

• Serotonin Receptor Interaction

L-THP interacts with serotonin (5-HT) receptors, contributing to calming and stabilizing effects observed in laboratory studies. 

• Alpha-Adrenergic Receptor Interaction

By binding to alpha-adrenergic receptors, L-THP influences the stress-response system and helps regulate arousal and blood vessel tone in laboratory models.

• Overall Neurochemical Effect in Experimental Models

Through these combined receptor actions, L-THP shows a balancing effect on brain activity, linked to sedative-, analgesic-, and anti-addictive–like effects in preclinical models.

What are the Potential Benefits of L-Tetrahydropalmatine (L-THP)?

L-Tetrahydropalmatine (L-THP) is still under investigation; however, preliminary studies have shown its following potential benefits in research subjects. 

• It may promote reduced anxiety in laboratory models.
• May influence blood vessel tone in laboratory models.
• It may serve as a reference standard in analytical testing.
• Some studies suggest L-THP may help shield nerve cells from damage during lab experiments. 

What are the Potential Side Effects of (-)-Tetrahydropalmatine?

The following potential side effects have been observed in preclinical settings. 

• May cause signaling pathway disruption.
• May reduce cell activity in some conditions.
• May alter neurotransmitter signaling in laboratory models. 
• May exhibit instability under certain laboratory conditions. 

Why choose RCDbio for L-Tetrahydropalmatine (L-THP)?

RCDbio provides research chemicals, laboratory-grade extracts, and peptides with third-party testing for quality and purity standards. We aim to be your trusted online source for this research-grade powder and other research-grade compounds. In addition, we provide a quick and secure transaction experience to our buyers.

FAQs

What is the shelf life of L-Tetrahydropalmatine (L-THP) powder?

L-Tetrahydropalmatine (L-THP) powder typically remains stable for up to 24 months. Stability is supported by controlled laboratory observations.

What are the recommended storage conditions for L-THP?

L-THP powder should be kept in a tightly sealed container, away from moisture and heat.

Does L-Tetrahydropalmatine (L-THP) maintain stability for laboratory applications?

Yes. The purified alkaloid form demonstrates reliable structural stability, allowing consistent outcomes in experimental testing.

How is L-Tetrahydropalmatine (L-THP) different from other alkaloids?

Unlike many general alkaloids, L-THP is a levorotatory isoquinoline alkaloid with defined receptor-binding activity, which makes it applicable in preclinical research settings.

How is the quality of L-Tetrahydropalmatine (L-THP) ensured?

The product is manufactured under controlled laboratory conditions, providing high-purity powder with reproducibility across experimental studies.

Disclaimer

L-Tetrahydropalmatine (L-THP) is exclusively for laboratory research purposes. RCDbio products are not intended to diagnose, prevent, or cure any disease. 

The Food and Drug Administration has not evaluated the statements on our website. Researchers must comply with all applicable local laws and regulations. By purchasing, you agree to our Terms and Conditions. In addition, RCDbio reserves the right to refuse sales to unauthorized individuals. 

For queries, complaints, or support, contact support@rcdbio.co.