HEP-1

Description

HEP-1 Peptide

HEP-1 is a short chain of amino acids synthetically formulated in research laboratories that mimics a specific portion of Azurin protein. Specifically, it imitates the α-domain. The peptide contains 14 amino acid residues and is often called tetradeca peptide.

In laboratory settings, the composition of HEP-1 peptide includes Threonine (Thr), Glutamic acid (Glu), Lysine (Lys), and Arginine (Arg). It also includes Valine (Val), a branched-chain amino acid that stabilizes its structure. 

The research-grade peptide is being explored for its mechanism of simultaneously inhibiting the expression of pro-inflammatory cytokines like IL-6, IL-1β, and TNFα. Additionally, in laboratory studies, HEP-1 peptide is a subject of interest due to its properties such as immune modulation, tissue repair, tissue protection, and antiviral activities. 

Chemical Properties 

Product Name	HEP-1
Molar Mass	1.6 kilodaltons
Chemical Formula	C74H132N26O27
Synonyms	HY-P10056
IUPAC Name	Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu

What is the Working Mechanism of HEP-1 Peptide?

Research-based studies on experimental models have shown that the research-grade peptide may act through multiple biological pathways. Here is a detailed breakdown of the HEP-1 peptide mechanism:

• When misfolded proteins build up under laboratory settings, HEP-1 helps balance the unfolded protein response by binding to regulatory domains on PERK, IRE1, and ATF6 sensors in the endoplasmic reticulum membranes. 

• Researchers suggest that the peptide may enhance the ER (Endoplasmic Reticulum) chaperone proteins by stabilizing their ATP-binding conformation. Thus, the peptide reduces oxidative stress in experimental models by facilitating the hydrolysis cycle, helping chaperones refold the misfolded proteins efficiently. 
• HEP-1 is believed to help in maintaining mitochondrial integrity by interacting with calcium-binding proteins in order to stabilize Ca²⁺ buffering and prevent excessive leakage. Thus, it helps in regulating calcium homeostasis in experimental models.

• Chronic ER stress in research models promoted inflammation via NF-κB and JNK pathways. The peptide downregulates inflammation by reducing the secretion of pro-inflammatory cytokines (e.g., IL-6, TNF-α). Additionally, it helps in increasing the antioxidant enzymes like catalase and superoxide dismutase.

What Are the HEP-1 Peptide Research Benefits?

In various laboratory settings, the following benefits of the synthetic researched peptide have been observed:

• It may support liver tissue regeneration in research subjects.
• It may reduce oxidative stress and inflammation in research models.
• It may modulate liver enzyme activity in laboratory settings.
• It may regulate hepatic gene expression in research models.
• It may enhance detoxification processes in laboratory models.

What Are the Potential Side Effects of the Peptide?

These are possible observed side effects under laboratory conditions:

• Temporary fatigue 
• Immune sensitization  
• Mild headaches 
• Insomnia 
• Mental overstimulation

Why Buy HEP-1 Peptide From RCDbio?

RCDbio provides research-grade peptides intended solely for laboratory research purposes. RCDbio aims to be your trusted online source for research-grade synthetic compounds. 

All our products are supported by a Certificate of Analysis (COA). In addition, we provide a quick and secure transactional experience to our buyers.

FAQs

What are the optimal storage conditions for HEP-1 Peptide?

The optimal storage recommendation is to store in a cool and dry place at −20 °C. Keep it protected from direct sunlight and moisture.

In what form does the peptide come in?

These peptides typically come as a freeze-dried powder (lyophilized form). It is easy for researchers to mix the peptide powder in different solutions for laboratory experiments. 

Is HEP-1 peptide approved for medical use in the USA?

No, the peptide powder is not yet approved by the FDA and is only available for preclinical research purposes. So, these peptide powders remain an investigational compound.

How should peptide powders be handled?

These compounds should be handled under controlled laboratory conditions, following standard laboratory safety protocols. 

Disclaimer

HEP-1 peptide powder formulations are intended exclusively for laboratory research purposes. RCDbio products are not intended to diagnose, treat, cure, or prevent any disease. The Food and Drug Administration has not evaluated the statements on our website. By purchasing, you agree to our Terms and Conditions.

For queries, complaints, or support, please contact support@rcdbio.co.