Dermorphin

Description

What is Dermorphin?

Dermorphin is an opioid receptor ligand (heptapeptide). It is originally isolated from the skin secretions of Phyllomedusa tree frogs. Dermorphin consists of seven amino acids. The seven amino acids are connected in a specific structure. The structure sequence is given below: 

H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂. 

It is one of the popular peptides among natural peptides as it contains a D-amino acid (D-alanine), which is unique. The amino acid may give dermorphin increased resistance against enzymatic breakdown to enhance its potency and duration of action in research subjects. 

Researchers study dermorphin for its potential pain-relieving and calming effects in controlled research environments. 

How Does Dermorphin Work? 

In different research settings, investigators have found that dermorphin works by binding to and activating the mu-opioid receptors (MORs). These receptors are part of the natural pain-regulation system in research subjects.

Upon binding to MORs, dermorphin mimics the action of endorphins, which are endogenous opioids. This may cause strong pain relief and other opioid-like effects in research subjects. Here are a few other working mechanisms of dermorphin:

• Signal Transduction 

Researchers have also noticed that dermorphin may activate G-protein-coupled pathways. By activating these pathways, dermorphin blocks adenylate cyclase and reduces the production of cAMP in research subjects. This leads to:

Decreased calcium influx and increased potassium efflux. It may also cause inhibition of neurotransmitter release (like substance P and glutamate) involved in pain transmission. 

What are the Potential Benefits of Dermorphin?

Researchers have observed the following benefits of dermorphin in different lab settings. 

• Potent pain relief in research subjects
• High mu-opioid receptor selectivity in research subjects
• Long-lasting effects in research subjects
• Lower tolerance development in research subjects
• Useful for studying opioid pathways in research subjects

What are the Potential Side Effects of Dermorphin?

Long-term research is needed to understand the safety profile of this compound. However, so far, researchers have observed the following side effects of dermorphin.

• Respiratory depression in research subjects
• Sedation in research subjects
• Motor impairment in research subjects
• Tolerance with repeated use in research subjects
• Dependency potential in research subjects

Where to Buy Dermorphin?

Buy dermorphin from RCDbio for an unforgettable experience. We have third-party tested and high-quality dermorphin for research purposes. We also provide you with the COA (certificate of analysis) with dermorphin for transparency and purity.  Furthermore, we make sure you do not have to go through any hindrance. Therefore, we offer secure transaction options.

FAQs

What is the legal status of Dermorphin?

Dermorphin is not approved for medical use. It is classified strictly as a research chemical for use in non-human studies only. (R)

What is the typical route of administration in research?

In research settings, dermorphin is commonly administered via injection (e.g., intrathecal or subcutaneous). This is due to its poor oral bioavailability.

How stable is Dermorphin in storage?

Dermorphin is generally stable when stored as a lyophilized powder at -20°C. Once reconstituted, it should be used promptly or stored at 2–8°C for short-term use.

What is its estimated half-life of Dermorphin in research models?

The exact half-life of dermorphin varies by model and dose. However, dermorphin shows a longer duration of action compared to many other opioid peptides due to its enzymatic resistance.

What is the difference between Dermorphin and Morphine?

Dermorphin and morphine both activate mu-opioid receptors. They produce strong analgesic effects. However, dermorphin is a natural peptide, while morphine is a plant-derived alkaloid.

Disclaimer

Dermorphin is exclusively for laboratory research purposes. RCDbio products are not intended to diagnose, prevent, or cure any disease. 

The Food and Drug Administration has not evaluated the statements on our website. Researchers must comply with all applicable local laws and regulations. By purchasing, you agree to our Terms and Conditions. In addition, RCDbio reserves the right to refuse sales to unauthorized individuals. 

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