Isotretinoin [Tablets]

Description

Isotretinoin [Tablets]

Preclinical findings have shown that Isotretinoin is a retinoid derived from vitamin A. It belongs to a retinoid class of lipophilic compounds. 

Isotretinoin’s stereochemistry influences its biological activity. Isotretinoin itself has low affinity for retinoid receptors, but it can isomerize into active metabolites such as all-trans-retinoic acid in controlled research environments.

Chemical Properties

Product Name	Isotretinoin Tablets
CAS	4759-48-2
Molar Mass	300.442 g·mol−1
Chemical Formula	C20H28O2
IUPAC Name	(2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
Synonyms	13-cis-retinoic acid

Working Mechanism of Isotretinoin

Laboratory experiments indicate that Isotretinoin interacts with several interconnected cellular pathways. Below is the potential experimental mechanism: 

• Modulation of Sebaceous Gland Activity

Preclinical findings suggest that Isotretinoin significantly reduces the size of sebaceous glands. The compound is also found to minimize the sebaceous gland activity. This mechanism lowers the production of sebum. 

The lower production of sebum helps in preventing acne development in laboratory models. 

• Regulation of Cellular Differentiation

Isotretinoin modulates gene expression indirectly. Since it has low affinity for nuclear receptors, instead, its metabolites, particularly all-trans-retinoic acid, exert stronger receptor-mediated effects. 

The modulation affects keratinocyte differentiation, cell cycle regulation, and apoptosis in experimental models.

• Anti-Inflammatory Effects

A few studies indicate that Isotretinoin decreases the release of inflammatory mediators such as cytokines. This action lowers inflammatory responses in controlled laboratory models.

• Apoptosis Induction

Laboratory studies suggest that Isotretinoin has the ability to trigger apoptosis. It means Isotretinoin is capable of programmed cell death. This action is helpful in decreasing the sebaceous gland size during preclinical research.

What are the Potential Benefits of Isotretinoin?

Isotretinoin is still under research investigation. However, preliminary studies may suggest the following potential observations:

• Act as a reference compound for retinoid-based research.
• Provide a reliable model for studying dermatological disorders.
• Serve as a reference compound in teratogenicity research models.
• Help researchers explore lipid metabolism pathways.
• Contribute to oncology research as a model for cell cycle regulation and apoptosis.

What are the Potential Side Effects of Isotretinoin?

The following potential side effects have been observed in preclinical and laboratory research:

• May cause dryness of epithelial tissues in experimental models.
• It has been observed to alter liver enzyme markers in preclinical assays.
• May lead to dose-dependent mucocutaneous changes in research settings.

Why Choose RCDbio to Buy Isotretinoin?

RCDbio provides research chemicals, laboratory-grade extracts, and peptides with third-party testing for quality and purity standards. We aim to be your trusted online source for research-grade tablets and other compounds. In addition, we provide a quick and secure transaction experience to our buyers.

FAQs

What is the shelf life of Isotretinoin [Tablets]?

It may remain stable for 2–3 years when stored under recommended laboratory conditions.

How can Isotretinoin be stored?

It is recommended to store it in a cool, dry place. The compound should be kept in a sealed container. 

What is the solubility of Isotretinoin?

The compound is partially soluble in water. Mostly, it is soluble in ethanol and dimethyl sulfoxide. 

Disclaimer

Isotretinoin [Tablets] are supplied strictly for laboratory research use only. RCDbio products are not intended to diagnose, treat, cure, or prevent any disease. 

The Food and Drug Administration has not evaluated the statements on our website. Researchers must comply with all applicable local laws and regulations. By purchasing, you agree to our Terms and Conditions. In addition, RCDbio reserves the right to refuse sales to unauthorized individuals. 

For queries, complaints, or support, contact support@rcdbio.co.