N-Acetyl L-Cysteine (NAC) [Powder]

Description

N-Acetyl L-Cysteine (NAC) [Powder]

Preclinical research has indicated that N-Acetyl L-Cysteine (NAC) [Powder] is a derivative of the naturally occurring amino acid L-cysteine. 

N-Acetyl L-Cysteine is chemically modified by combining an acetyl group to the nitrogen atom. This modification makes the compound more stable and bioavailable in lab experiments. 

In addition, NAC is classified as a thiol-containing compound. This classification is due to the presence of a free sulfhydryl (-SH) group in its molecular structure. The (-SH) group gives the compound a distinct sulfur-like odor during biochemical activities in laboratory experiments. 

Chemical Properties

PRODUCT TYPE	POWDER
Product Name	N-Acetylcysteine (NAC)
CAS	616-91-1
Molar Mass	163.19 g·mol−1
Chemical Formula	C₅H₉NO₃S
IUPAC Name	(2R)-2-acetamido-3-sulfanylpropanoic acid
Synonyms	acetylcysteine, mercapturic acid

What is the Working Mechanism of N-Acetyl L-Cysteine (NAC)?

In laboratory experiments, N-Acetyl L-Cysteine (NAC) has been shown to interact with multiple interconnected biochemical pathways. Here is a breakdown of its working mechanism:

• Precursor to Glutathione (GSH) Synthesis in Experimental Models

Preclinical and experimental research indicate that NAC acts as a prodrug for L-cysteine amino acid. This process is required to synthesize glutathione (GSH), one of the most significant intracellular antioxidants. As a result of the process, cysteine combines with glutamate and glycine to synthesize glutathione. 

It is found that in experimental models, enhanced glutathione levels boost the cell’s ability to neutralize reactive oxygen species (ROS). This effect helps to protect against oxidative stress in research models.

• Direct Free Radical Scavenging

Laboratory findings suggest that NAC itself contains a free sulfhydryl (-SH) group. This capability makes the compound able to directly interact with reactive oxygen species. Further, N-Acetyl L-Cysteine (NAC) can directly interact with electrophiles and reactive nitrogen species. 

The direct antioxidant action of NAC helps stabilize DNA, proteins, cellular structures, and lipids from oxidative damage in preclinical laboratory models. 

• Mucolytic Activity (Airway Secretions) 

According to laboratory and preclinical research, N-Acetyl L-Cysteine (NAC) has the ability to reduce the viscosity of mucus by breaking disulfide bonds within mucoproteins. The sulfhydryl group of NAC converts thick and sticky mucus into a thin secretion. 

It helps in convenient clearance of airway secretions in respiratory conditions of laboratory research models. 

• Modulation of Redox-Sensitive Signaling Pathways

Preclinical research indicates N-Acetyl L-Cysteine (NAC) influences several cellular pathways sensitive to oxidative stress:

NF-κB (Nuclear Factor kappa B): NAC may influence NF-κB activity, which regulates pro-inflammatory cytokine production in research models. 

Nrf2 (Nuclear factor erythroid 2-related factor 2): By increasing glutathione, NAC may support Nrf2 pathway activation, promoting antioxidant enzyme expression (e.g., glutathione peroxidase, catalase).

• Modulation of Neurotransmission (Glutamate Regulation)

N-Acetyl L-Cysteine (NAC) acts on the cystine-glutamate antiporter (system Xc⁻). By raising extracellular cystine, NAC indirectly modulates glutamate concentrations in the synaptic cleft. This action contributes to restoring glutamate homeostasis in experimental models.

What are the Potential Benefits of N-Acetyl L-Cysteine (NAC)?

N-Acetyl L-Cysteine (NAC) is still under investigation; however, preliminary studies suggest the following potential research observations. 

• May support detoxification pathways in chemical research models.
• May act as a source of cysteine in lab studies.
• May show protective effects in laboratory stress models.
• May alter pathways connected with brain chemistry in experiments. 

What are the Potential Side Effects of N-Acetyl L-Cysteine (NAC)?

The following potential side effects have been observed in preclinical settings. 

• May cause nausea and headache during lab experiments. 
• May cause dizziness in certain research models.
• May cause lower blood pressure under certain laboratory conditions.
• May show instability when exposed to air. 

Why choose RCDbio for N-Acetyl L-Cysteine (NAC)?

RCDbio provides research chemicals, laboratory-grade extracts, and peptides with third-party testing for quality and purity standards. We aim to be your trusted online source for this research-grade powder and other research-grade compounds. In addition, we provide a quick and secure transaction experience to our buyers.

FAQs

What is the shelf life of N-Acetyl L-Cysteine (NAC)?

NAC powder may remain stable for 2–3 years if stored under recommended conditions.

What are the recommended storage conditions for NAC?

N-Acetyl L-Cysteine (NAC) powder should be kept in a sealed container, away from moisture, heat, and direct sunlight.

Is NAC powder water-soluble?

Yes, NAC is water-soluble and can dissolve readily in aqueous solutions for research purposes.

How does NAC function in research models?

It may interact with oxidative pathways, support detoxification studies, and influence cellular activity under controlled laboratory settings.

Disclaimer

N-Acetyl L-Cysteine (NAC) is exclusively for laboratory research purposes. RCDbio products are not intended to diagnose, treat, cure, or prevent any disease. 

The Food and Drug Administration has not evaluated the statements on our website. Researchers must comply with all applicable local laws and regulations. By purchasing, you agree to our Terms and Conditions. In addition, RCDbio reserves the right to refuse sales to unauthorized individuals. 

For queries, complaints, or support, contact support@rcdbio.co.