SR-9011 [Liquid]

Description

SR-9011 [Liquid]

SR-9011 is a small-molecule synthetic research compound. It acts as an agonist of nuclear receptors known as REV-ERB proteins (REV-ERBα and REV-ERBβ) in experimental research models.
As per laboratory evidence, REV-ERB receptors are implicated in regulating circadian rhythm, metabolic gene expression, and inflammatory pathways in research models. In laboratory settings, SR-9011 is researched to bind REV-ERB receptors to stabilize their repressive transcriptional activity.

Chemical Properties 

Product Name	SR 9011
CAS	1379686-29-9
Molar Mass	479.04 g/mol
Chemical Formula	C23H31ClN4O3S
IUPAC Name	3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]-N-pentylpyrrolidine-1-carboxamide

What Is the Working Mechanism of  SR-9011 [Liquid]?

Research-based studies on experimental models have shown that SR-9011 [Liquid]

may act through multiple biological pathways. Here is a detailed  breakdown of its working mechanism:

• Binding to REV-ERB Receptors

Studies suggest that SR-9011, upon entering the cell nucleus, binds to the ligand-binding domain of REV-ERBα/β. It may stabilize the receptor’s active conformation. This increases the receptor’s ability to interact with DNA-associated proteins.

• Recruitment of Corepressors
  

Upon activation, REV-ERB proteins recruit corepressor complexes, primarily NCoR (Nuclear Receptor Corepressor) and HDAC3 (Histone Deacetylase 3).  These enzymes remove acetyl groups from histones, resulting in:

• Tighter DNA packing
• Decreased accessibility to transcription machinery
  

• Modulation of Metabolic Pathways

Through REV-ERB activation, SR-9011 indirectly affects genes involved in fat storage, glucose metabolism, and energy utilization in experimental models. 

• Mitochondrial Function Effects 

SR-9011 liquid may influence proteins associated with mitochondrial function. It has been shown in cell studies to affect mitochondrial biogenesis-related pathways. It may help reduce oxidative stress markers under laboratory conditions.

What Are the Potential Research Observations of  SR-9011 [Liquid]?

While SR-9011 liquid formulations are still under research, some areas of scientific interest include:

• Has been observed to reduce hepatic fat accumulation in rodent models.
• It may be studied for metabolic disorders in laboratory settings.
• It may have the potential to reduce inflammatory markers. 
• May influence circadian gene expression. 

What Are the Potential Research Side Effects of  SR-9011 [Liquid]?

The following may be observed as side effects of the compound in research settings:

• May elevate heart rate markers in research models. 
• Has been observed to alter hepatic lipid accumulation in rodent research models.
• May cause a transient headache.
• It may affect liver-related biochemical markers in experimental conditions.

Why Buy SR-9011 [Liquid] From RCDbio?

RCDbio provides research-grade liquid formulations intended solely for laboratory research purposes. RCDbio aims to be your trusted online source for research-grade synthetic compounds. 

All our products are supported by a Certificate of Analysis (COA). In addition, we provide a quick and secure transaction experience to our buyers. 

FAQs

What is the shelf life of SR-9011 liquids?

The shelf life of SR-9011 liquids is typically up to 12 months when stored under recommended conditions.

What are the optimal storage conditions?

The optimal storage recommendation is to store SR-9011 liquids between 2°C and 8°C in a cool and dry environment. Keep it protected from direct sunlight and moisture.

Can SR-9011 liquids be dissolved in solvents?

It may be solubilized in ethanol, DMSO, or other laboratory-appropriate solvents.

Disclaimer

SR-9011 liquids are intended exclusively for laboratory research purposes. RCDbio products are not intended to diagnose, treat, cure, or prevent any disease. 

The Food and Drug Administration has not evaluated the statements on our website. Researchers must comply with all applicable local laws and regulations. By purchasing, you agree to our Terms and Conditions. 

For queries, complaints, or support, please contact support@rcdbio.co.