AC-Semax NH2 10mg

Description

What is AC-Semax NH2 Peptide?

AC-Semax NH2 (N-Acetyl Semax Amidate) is a synthetic heptapeptide derived from a structural fragment of adrenocorticotrophic hormone (ACTH 4-10). 

The acetylation of the N-terminus and amidation of the C-terminus distinguish it from its parent compound, Semax, conferring enhanced peptide stability and modified receptor interaction profiles.

 AC-Semax NH2 is classified as an investigational neuropeptide analog and is studied in preclinical research settings for its interaction with melanocortin receptor subtypes and neurotrophic signaling pathways.

Chemical Properties

Product Type	Peptides
Product Name	AC-Semax NH2 (N-Acetyl Semax Amidate)
PubChem CID	172638603
Application	Scientific Research
CAS	2920938-90-3
Molar Mass	854.97 g·mol⁻¹
Chemical Formula	C₃₉H₅₄N₁₀O₁₀S
Sequence	Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂
Synonyms	N-Acetyl Semax Amidate, Acetyl Semax Amide

How Does AC-Semax NH2 Peptide Work?

Preclinical research suggests that AC-Semax NH2 interacts with melanocortin receptor subtypes located within neuroendocrine signaling networks. 

Upon receptor engagement, investigational data indicate involvement of downstream neurotrophic pathways, particularly those associated with brain-derived neurotrophic factor (BDNF) expression and TrkB receptor activation. 

The acetylated and amidated terminal modifications are associated with increased resistance to enzymatic degradation in preclinical settings, potentially prolonging receptor-mediated signaling activity. Research also suggests interaction with monoaminergic transmission pathways, with observed modulation of dopaminergic and serotonergic receptor activity in in vitro preclinical models.

Preclinical Investigational Findings

In controlled research environments, preclinical studies have investigated AC-Semax NH2 for the following areas of interest:

• Modulates neurotrophic factor expression within investigational neural signaling networks
• Influences melanocortin receptor-mediated neuroendocrine pathway activity
• Associated with the regulation of monoaminergic receptor transmission in preclinical settings
• Observed to interact with antioxidative signaling cascades in in vitro investigational studies
• Preclinical data suggest involvement in hypoxia-response signaling pathway regulation

Safety Profile and Toxicological Considerations

The following observations are derived exclusively from preclinical in vitro research settings. No human safety profile has been established for AC-Semax NH2. Long-term toxicological data remain absent:

• Potential disruption of melanocortin receptor sensitivity under prolonged investigational exposure
• May alter baseline neurotrophic signaling parameters in preclinical research models
• Observed variability in monoaminergic pathway responses across differing research concentrations
• Possible modulation of neuroendocrine feedback loop dynamics in investigational settings
• Risk of off-target receptor interactions at elevated research concentrations

Where to Buy AC-Semax NH2 Peptide?

If you are planning to purchase the AC-Semax NH2 peptide, you should buy it from RCDbio. Our online shop provides third-party tested, research-grade AC-Semax NH2 peptide meeting verified purity standards. We offer secure transaction methods to protect your privacy and ensure the fastest delivery of your products.

FAQs

What is the half-life of AC-Semax NH2 peptide in research settings?

AC-Semax NH2 demonstrates an extended stability profile compared to unmodified Semax, owing to its N-terminal acetylation and C-terminal amidation. In preclinical in vitro conditions, the compound exhibits enhanced resistance to peptidase-mediated degradation, with investigational data suggesting a prolonged functional presence relative to non-amidated analogs.

What is the recommended shelf life of AC-Semax NH2 in storage?

When stored in lyophilized form at −20°C, AC-Semax NH2 peptide may remain stable for up to 24 months. Long-term preservation of compound integrity requires protection from light, moisture, and temperature fluctuation throughout the storage period.

How stable is AC-Semax NH2 in reconstituted form? 

Upon reconstitution, AC-Semax NH2 is stable for approximately 2 weeks at 4°C and for several months at −20°C when stored in aliquoted form. Repeated freeze-thaw cycles should be avoided to prevent degradation of peptide structure and reduction in investigational activity.

Has AC-Semax NH2 shown toxicity indicators in preclinical research? 

Available preclinical data indicate a low toxicity profile for AC-Semax NH2 at research concentrations evaluated in controlled in vitro and investigational settings. However, concentration-dependent variables have been observed, and the long-term safety profile remains incompletely characterized, necessitating further systematic investigation.

What conditions affect the stability of the AC-Semax NH2 peptide? 

Exposure to elevated temperatures, prolonged UV light, repeated freeze-thaw cycling, and aqueous conditions at non-neutral pH values may compromise the structural integrity of AC-Semax NH2. Lyophilized storage under recommended conditions is advised to maintain compound viability throughout the research period.

Disclaimer

AC-Semax NH2 peptide is exclusively for laboratory research purposes. RCDbio products are not intended to diagnose, prevent, or cure any disease. The Food and Drug Administration has not evaluated the statements on our website. Researchers must comply with all applicable local laws and regulations. 

By purchasing, you agree to our Terms and Conditions. In addition, RCDbio reserves the right to refuse sales to unauthorized individuals.

For queries, complaints, or support, contact support@rcdbio.co

References

Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Zolotarev YA, Kamensky AA, Grivennikov IA, Engele J, Myasoedov NF. Semax, an analogue of ACTH(4-7), regulates BDNF and trkB expression in the rat hippocampus. Brain Research. 2006;1117(1):54–60. PMID: 16962074.https://pubmed.ncbi.nlm.nih.gov/16962074/ 

Gudasheva TA, Antipova TA, Konstantinopolsky MA, Seredenin SB. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. Eur J Pharmacol. 2006;536(3):258–262. PMID: 16635254.https://pubmed.ncbi.nlm.nih.gov/16635254/