Gonadorelin [Peptide]

Description

Gonadorelin [Peptide]

The product is only intended for laboratory research use and not for human consumption. 

Available quantities:

• 2 mg
• 5mg
• 10mg

Product Information 

Product name	Gonadorelin
Peptide purity (HPLC)	98-99%
Molecular Formula	C59H83N17O17
Molecular Weight	1182.3mol
Synonyms	Gonadorelina, GnRH-I, Luteinizing hormone-releasing hormone (LH-RH)
CAS	33515-09-2
Source	Synthetic
Form	Powder
Shelf Life	Up to 2 years in powder form under recommended conditions

Molecular Sequence of Gonadorelin [Peptide] Peptide 

pGlu–His–Trp–Ser–Tyr–Gly–Leu–Arg–Pro–Gly–NH₂

Or in full N- to C-terminus notation:

H–pGlu–His–Trp–Ser–Tyr–Gly–Leu–Arg–Pro–Gly–NH₂

Residue Key / Explanation

• pGlu = Pyroglutamic acid (cyclized glutamate at the N-terminus)
• His = Histidine
• Trp = Tryptophan
• Ser = Serine
• Tyr = Tyrosine
• Gly = Glycine
• Leu = Leucine
• Arg = Arginine
• Pro = Proline
• NH₂ = C-terminal amidation (amide group instead of –OH)

Handling and Storage of Gonadorelin Peptide 

The peptide compound should be stored in a cool and dry place to maximize its stability. For better storage, it is recommended to keep the Gonadorelin lyophilized peptides refrigerated between 2°C and 8°C (36°F–46°F) in an air-sealed container.

Lab user exposure	Redissolving	Choice of container and precautions
Wear laboratory coats, nitrile gloves, and eye protection.  Avoid prolonged or repeated exposure and avoid inhalation. Avoid contact with eyes or skin. The product is non-hazardous for lab-to-lab or air transportation. Handle inside standard laboratory containment.	Can be reconstituted in sterile distilled water or suitable buffer solutions. A small amount of DMSO or 0.1% TFA may be used to test or improve solubility. Mix gently, avoid high-temperature heating.	Low-binding sterile polypropylene to prevent absorption. Borosilicate glass vials to prevent absorption in the glass walls.  Avoid polystyrene and lab plastic containers. Avoid amber vials or opaque containers.

Overview of the Gonadorelin 

The research-grade Gonadorelin is a decapeptide. It is structurally identical to naturally occurring GnRH which is a key regulatory hormone in research models of the endocrine system. As per preclinical research, Gonadorelin plays a significant role in controlling reproductive function and pushing the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland.

Gonadorelin is widely used in biomedical, endocrinology, and reproductive research to study hypothalamic-pituitary-gonadal (HPG) axis signaling, hormone pulsatility, fertility mechanisms, and pituitary responsiveness.

This product is supplied as a high-purity peptide intended strictly for laboratory and research applications. It is optimized for use in in-vitro studies, receptor binding assays, endocrine pathway investigations, and controlled experimental models.

Working Mechanism of the Peptide

Preclinical and laboratory studies demonstrate that Gonadorelin functions as the primary upstream regulator of the reproductive hormone cascade via the following mechanisms:

• Gonadorelin binds to GnRH receptors on pituitary gonadotroph cells, initiating intracellular signaling pathways (primarily via G-protein coupled receptor mechanisms).

Once bound, Gonadorelin triggers the release of:

• Luteinizing Hormone (LH) – involved in ovulation and testosterone production
• Follicle-Stimulating Hormone (FSH) – involved in gamete development and estrogen regulation

Through pulsatile signaling, Gonadorelin controls:

• Puberty onset
• Fertility regulation
• Gonadal hormone production
• Gonadorelin activity is tightly regulated by feedback from sex steroids (testosterone, estrogen, progesterone), making it a key model compound in endocrine feedback studies.

Besides potential mechanisms, here are some common side effects of the compound observed in different research models:

• Nausea 
• Fatigue
• Dizziness
• Headache

TFA Salt Form 

Gonadorelin is provided in its TFA salt form. Residual trifluoroacetate content is typically up to 10% w/w. It depends on the final formulation and lyophilization conditions. The exact TFA content can be confirmed by batch-specific COA.

Disclaimer

Gonadorelin peptide is intended exclusively for laboratory research purposes. RCDbio products are not intended to diagnose, treat, cure, or prevent any disease. The Food and Drug Administration has not evaluated the statements on our website. By purchasing, you agree to our Terms and Conditions.

For queries, complaints, or support, please contact support@rcdbio.co.