Orexin B

Description

Orexin B

Orexin B, also known as Hypocretin-2, is a neuropeptide. It is a small protein-like molecule. As observed in lab models, it is produced by neurons in the lateral hypothalamus to send messages to other neurons. Additionally, Orexin B has a closely related peptide, Orexin A (Hypocretin-1).

Researchers study this peptide for its potential to regulate sleep-wake cycles and arousal in research settings. As it is suggested that the dysfunction of Orexin A and B is linked to narcolepsy in experimental models.

Chemical Properties 

Product Name	Orexin B
CAS	205599-76-4
Molar Mass	3.1 kDa
Chemical Formula	C137H228N44O38
Synonyms	Orexin-B, hypocretin-2, Orexin B, DTXSID601053004, 205599-76-4
IUPAC Name	L-methionyl-L-threonyl-L-leucyl-L-isoleucyl-glycyl-L-alanyl-L-alanyl-L-histidyl-L-asparagyl-glycyl-L-seryl-L-alanyl-L-glutaminyl-L-leucyl-L-leucyl-L-arginyl-L-glutaminyl-L-leucyl-L-arginyl-glycyl-L-glutaminyl-L-leucyl-glycyl-L-prolyl-L-prolyl-glycyl-L-seryl-L-argininamide

What is the Working Mechanism of Orexin B Peptide?

Research-based studies on experimental models have shown that Orexin B research peptides may act through multiple biological pathways. Here is a detailed breakdown of its working mechanism:

• Studies suggest that, Orexin B may travel through neural spaces and bind themselves to specific receptors (OX₁R Orexin receptor 1 and OX₂R Receptor 2), in order to target nerve cells. By binding to these receptors, the peptide may activate G-protein-coupled signaling pathways. 
• By binding to the specific receptor the 
• Gq and Gs proteins are triggered, which then activate cell enzymes to increase the levels of cyclic AMP (cAMP) and intracellular calcium (Ca²⁺). 
• Thus, in experimental models the increased cAMP and Ca² levels makes the neurons more active, sending electrical impulses to other brain areas under laboratory conditions.
• Finally, the receptors promoted through Orexin B have multiple effects. In locus coeruleus the receptors release norepinephrine to promote alertness and focus, in the tuberomammillary nucleus, it releases histamine to keep the brain active, in the raphe nucleus releases serotonin in order to regulate mood and emotional balance under laboratory settings. 
• In addition, in the ventral tegmental area (VTA) Orexin B may increase dopamine activity, enhancing the motivation in laboratory models. 

What Are the Orexin B Peptide Research Benefits?

In various laboratory settings, the following benefits of the researched peptide have been observed:

• It may promote wakefulness in research models.
• It may stabilize sleep-wake cycles in research settings.
• It may boost alertness in research subjects.
• It may support stress response in laboratory models.

What Are the Potential Side Effects of the Peptide?

These are possible observed side effects under laboratory conditions:

• Anxiety
• Increased appetite   
• Mild headache 
• Insomnia 
• Nervous system overstimulation

Why Buy Orexin B From RCDbio?

RCDbio provides research-grade peptides intended solely for laboratory research purposes. RCDbio aims to be your trusted online source for research-grade synthetic compounds. 

All our products are supported by a Certificate of Analysis (COA). In addition, we provide a quick and secure transactional experience to our buyers.

FAQs

What are the optimal storage conditions for Orexin B research-grade peptides?

The optimal storage recommendation is to store in a cool and dry place at −20 °C. Keep it protected from direct sunlight and moisture.

In what form does the peptide come in?

These peptides typically come as a freeze-dried powder (lyophilized form). It is easy for researchers to mix the peptide powder in different solutions for laboratory experiments. 

Is Orexin B approved for medical use in the USA?

No, Orexin B peptide powder is not yet approved by the FDA and is only available for preclinical research purposes. So, these peptide powders remain an investigational compound.

Disclaimer

Orexin B peptide formulations are intended exclusively for laboratory research purposes. RCDbio products are not intended to diagnose, treat, cure, or prevent any disease. The Food and Drug Administration has not evaluated the statements on our website. By purchasing, you agree to our Terms and Conditions.

For queries, complaints, or support, please contact support@rcdbio.co.